Mitochondrial disorders vary widely in presentation and age of onset. The L:P ratio is elevated in several, but not all, mitochondrial respiratory chain disorders. Though isolated elevated pyruvate is not diagnostic of any inborn error of metabolism, analysis with lactate may suggest an inborn error of metabolism as some present with lactic acidosis or a high lactate-to-pyruvate (L:P) ratio. It is also a good idea to visit your GP if you develop any of the symptoms noted above.Pyruvic acid, an intermediate metabolite, plays an important role in linking carbohydrate and amino acid metabolism to the tricarboxylic acid cycle, the fatty acid beta-oxidation pathway, and the mitochondrial respiratory chain complex. It may be a good idea to have regular check ups with your GP to monitor your level, so that if there any changes these can be investigated further. I would say if you continue to feel well then it would be best to try not to worry about this. If you have seen a specialist it’s likely that they have looked into all of the possible underlying causes, and in your case do not feel that any further input is required. Possible causes of an increased MCV count: Thalassaemia (an inherited blood disorder that affects the amount of haemoglobin a person creates).The fact that they do not seem concerned should be reassuring for you.įor information, there are some underlying health conditions that may lead to an abnormal MCV count Reduced MCV can indicate: I am glad that you've spoken to your GP and seen the appropriate specialist doctor in the Haematology team. However please note that these symptoms are quite general in nature and can be related to a number of different causes, so it’s always best to discuss your symptoms with your doctor. Symptoms of abnormal MCV (either high of low) may include: When we have an abnormal MCV count, a number of symptoms may become apparent. The fact that your result has remained stable over three years is a good sign that would likely indicate that if there was any underlying cause, this doesn’t appear to be worsening. The normal reference range for the MCV result is usually between 80-100fl, so you are right, your level is slightly above the normal reference range.
Red blood cells are responsible for transporting oxygen from our lungs to all other areas of the body, so it’s important that we know whether these are ‘healthy’ or not. You may have found that your MCV level is slightly raised incidentally as part of a routine blood test, or this may have been specifically tested to try and discover a cause for any underlying symptoms. The MCV or ‘Mean Corpuscular Volume’ count, is tested as part of a routine blood test called the ‘Full Blood Count’ and measures the average size of our red blood cells.
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